Historical Context
The synaxarion situates Anastasia's martyrdom in the period of the mid-third-century persecutions. Her recorded date of death, between 256 and 259, falls within the Valerian persecution (253–260), during which the emperor Valerian issued imperial edicts ordering Christian clergy to sacrifice to the pagan gods, forbidding the use of cemeteries, and later commanding the execution of bishops and senior church officials and the stripping of titles from Christian senators and equestrians.
That same period produced a number of well-known martyrs, including Pope Sixtus II, the deacon Lawrence, Cyprian of Carthage, and Denis of Paris. The persecution ended in 260, when Gallienus succeeded Valerian and revoked the anti-Christian legislation.