Barses, Eulogius, and Protogenes were three bishops of Mesopotamia who suffered exile and persecution in the second half of the fourth century for refusing to abandon the Nicene faith during the Arian campaign of the emperor Valens (reigned 364-378). They are commemorated together on August 25. Their story is preserved in the Orthodox synaxarion, which presents them as confessors who endured banishment rather than embrace the heresy favoured by the imperial court.
Barses occupied the episcopal throne of Edessa and was esteemed as a defender of Orthodoxy. According to the tradition, Valens removed him from his see and sent him into a succession of ever more distant exiles: first to the island of Arad, then to Oxyrhynchos in Egypt, and finally to the remote frontier city of Thenon, where, worn out by his banishments, he died. The presbyters Eulogius and Protogenes were likewise persecuted and exiled to Antinoe in the Egyptian Thebaid, then still a centre of paganism.
Rather than perishing in exile, Eulogius and Protogenes turned their banishment into a mission: by their preaching they brought many idol-worshippers to Christ and baptized them. When Valens died and was succeeded by the emperor Theodosius (reigned 379-395), the surviving Orthodox confessors were recalled. In place of the deceased Barses, Eulogius was elevated as Bishop of Edessa, and Protogenes was made bishop of the Mesopotamian city of Carrhae. Both are said to have guided their flocks until their deaths near the close of the fourth century.