Early Life and Monastic Career
Serapion originated from Pekhorka, a village in the Moscow region now identified with Pekhra-Pokrovskoye, part of Balashikha in present-day Moscow Oblast. He married and was ordained a priest, but was widowed within a year of his marriage.
Following his wife's death, he was tonsured a monk at the Dubensky Dormition Monastery in Vladimir province, where he eventually became hegumen. He subsequently served as hegumen of the Stromynsky Dormition Monastery; both institutions were later liquidated in the eighteenth century. In the mid-1490s he assumed leadership of the Trinity Monastery, later renowned as the Holy Trinity-St. Sergius Lavra.
Archbishop of Novgorod
On the initiative of Grand Prince Vasily III of Moscow, Serapion was consecrated and enthroned as Archbishop of Novgorod and Pskov on January 15, 1506, despite his initial refusal of the office. His tenure lasted a little over three years.
The defining conflict of his episcopate arose in 1507, when Joseph of Volokolamsk, who fell within Serapion's episcopal jurisdiction, transferred his monastery to princely patronage. Serapion responded by depriving Joseph of his blessing and excommunicating him. Joseph then appealed directly to Simon, Metropolitan of Moscow, bypassing his archbishop — an action Serapion deemed anti-canonical. Sources record Serapion's complaint that Joseph had 'abandoned heaven and descended to earth,' language the Grand Prince interpreted as a personal affront to his divinely sanctioned authority.
Removal, Confinement, and Final Years
In July 1509 a synod found Serapion at fault, removed him from his see, and confined him to the Andronikov Monastery in Moscow, where he endured harsh conditions. The sources record that he bore this imprisonment with great humility and patience.
He was released in 1511 and spent his remaining years at the Trinity Monastery, where he reposed on March 16, 1516. After his death the See of Novgorod remained vacant for seventeen years, until 1526. He is venerated as a saint in the Russian Orthodox Church, with a feast day on March 16.