Historical Context
The two ascetics belong to the distinctive monastic tradition of northern Syria during the fourth and early fifth centuries. Their chief historical witness is Theodoret of Cyrrhus (born c. 393 in Antioch, appointed Bishop of Cyrrhus in 423, died c. 458-460), whose Philotheos historia, or A History of the Monks of Syria, is generally dated to around 444 CE.
Theodoret's fluency in Syriac and his role as bishop of the Cyrrhestica region gave him intimate knowledge of the local ascetic communities he described. He presented his thirty subjects as religious models; the last ten among them were still living when the work was completed.
In the Historia Religiosa, Asclepius and James appear grouped with Zebinas and Polychronius as ascetics of Cyrrhestica. The figures are listed together without individual death dates, which suggests they were contemporaries.